Advancing our understanding of the neurobiology of anorexia nervosa: translation into treatment

About this resource

Anorexia nervosa (AN) is a severe mental disorder predominantly affecting young women. Less than half of patients recover following treatment. For the past 20 years, substantial research has been invested into the identification of the neurobiological underpinnings. Structural brain imaging studies have shown gray and white matter changes which generally normalize with recovery. Functional brain imaging studies have demonstrated alterations in fronto-striato-limbic circuits, suggesting aberrant cognitive control, reward, and emotion processes. This suggests AN psychopathology emerge as a result of altered interactions between top-down and bottom-up circuits, possibly related to core disturbances in how the brain processes salient stimuli. Below we point to examples of how advances in our understanding of the neurobiology of anorexia nervosa, focusing on neuroimaging studies of brain structure and function, can be translated into treatment.

AuthorBang, Lasse; Treasure, Janet; Ro, Oyvind; Joos, Andreas
JournalJournal of Eating Disorders
Year2017

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