Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation treatment of posttraumatic stress disorder in eating disorders: An open-label case series

About this resource

Posttraumatic stress disorder (PTSD) is a common comorbid condition in anorexia nervosa (AN) and bulimia nervosa (BN), and may be associated with reduced response to treatment. We report on a case series employing repetitive transcranial magnetic stimulation (rTMS) with a novel target, the dorsomedial prefrontal cortex (DMPFC). Fourteen subjects with eating disorders and comorbid PTSD received 20–30 neuronavigated DMPFC–rTMS treatments on an open-label basis. PTSD symptoms were assessed pretreatment and posttreatment with the PTSD checklist-Civilian (PCL-C) and the Difficulties in Emotional Regulation Scale (DERS). PCL-C scores were reduced by 51.99% ± 27.24% overall, from a mean of 54.29?±?19.34 pretreatment to 24.86?±?17.43 posttreatment (p?50%. DERS scores improved by 36.02% ± 24.24% overall, from 140.00?±?22.09 at pretreatment to 89.29?±?38.31 at posttreatment (p?50% improvement. These data may suggest that DMPFC–rTMS could be helpful in the treatment of PTSD in some ED patients.

AuthorWoodside, D. Blake; Colton, Patricia; Lam, Eileen; Dunlop, Katharine; Rzeszutek, Julia; Downar, Jonathan
JournalInternational Journal of Eating Disorders
Year2017

See also

Ten session body image therapy: Efficacy of a manualised body image therapy

OBJECTIVE: To determine the efficacy of 10 session body image therapy (BAT-10) in the treatment of anorexia nervosa with adherence to the methodological guidance for complex interventions.

Read more

Assessment of patients with anorexia nervosa: Interview versus self-report

ABSTRACT Objective Inefficient cognitive flexibility is considered a neurocognitive trait marker involved in the development and maintenance of anorexia nervosa (AN).

Read more

Classification of childhood onset eating disorders: A latent class analysis

This study tested the hypothesis that latent class analysis (LCA) would successfully classify eating disorder (ED) symptoms in children into categories that mapped onto DSM-5 diagnoses and that these categories would be consistent across countries.

Read more

Low weight gain at the start of a family-based intervention for adolescent girls with restrictive eating disorders predicted emergency hospital admission

Aim: This study examined predictors of emergency hospitalisation of adolescent girls with restrictive eating disorders and weight loss treated by a family-based intervention programme.

Read more

Help us improve!

Give us feedback!

We will continue throughout 2020 to update and improve the NEDC website and welcome any feedback you may have on the site.

Provide feedback