Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation treatment of posttraumatic stress disorder in eating disorders: An open-label case series

About this resource

Posttraumatic stress disorder (PTSD) is a common comorbid condition in anorexia nervosa (AN) and bulimia nervosa (BN), and may be associated with reduced response to treatment. We report on a case series employing repetitive transcranial magnetic stimulation (rTMS) with a novel target, the dorsomedial prefrontal cortex (DMPFC). Fourteen subjects with eating disorders and comorbid PTSD received 20–30 neuronavigated DMPFC–rTMS treatments on an open-label basis. PTSD symptoms were assessed pretreatment and posttreatment with the PTSD checklist-Civilian (PCL-C) and the Difficulties in Emotional Regulation Scale (DERS). PCL-C scores were reduced by 51.99% ± 27.24% overall, from a mean of 54.29?±?19.34 pretreatment to 24.86?±?17.43 posttreatment (p?50%. DERS scores improved by 36.02% ± 24.24% overall, from 140.00?±?22.09 at pretreatment to 89.29?±?38.31 at posttreatment (p?50% improvement. These data may suggest that DMPFC–rTMS could be helpful in the treatment of PTSD in some ED patients.

AuthorWoodside, D. Blake; Colton, Patricia; Lam, Eileen; Dunlop, Katharine; Rzeszutek, Julia; Downar, Jonathan
JournalInternational Journal of Eating Disorders

See also

Memory versus perception of body size in patients with anorexia nervosa and healthy controls

The objective of this study was to compare body size estimation based on memory versus perception, in patients with anorexia nervosa (AN) and healthy controls, adjusting for possible confounders.

Read more

Short- and long-term outcome of males treated for anorexia nervosa: a review of the literature.

PURPOSE: To give an overview of existing studies on the short- and long-term outcome for males treated for anorexia nervosa and to compare the outcome between adolescents and adults as well as between males and females.

Read more

Treatment of anorexia nervosa in a specialty care continuum

OBJECTIVE: Inpatient hospitalization has been a mainstay of treatment for anorexia nervosa (AN), but decreasing lengths of inpatient stay have prompted the development of alternative care-continuum models.

Read more

Adipocytokine levels in women with anorexia nervosa. Relationship with weight restoration and disease duration

Objective: Starvation-induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines.

Read more

Help us improve!

Give us feedback!

We will continue throughout 2019 to update and improve the NEDC website and welcome any feedback you may have on the site.

Provide feedback