Subcortical Shape Abnormalities in Bulimia Nervosa.

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BACKGROUND: Bulimia nervosa (BN) is associated with functional abnormalities in frontostriatal and frontolimbic circuits. Although structural alterations in the frontal portions of these circuits have been observed, this is the first study of subcortical surface morphometry and the largest study of subcortical volume in BN. METHODS: Anatomical magnetic resonance scans were acquired from 62 female participants with full and subthreshold BN (mean age +/- SD, 18.7 +/- 4.0 years) and 65 group-matched healthy control participants (mean age +/- SD, 19.3 +/- 5.7 years). General linear models were used to compare groups and assess the significance of group-by-age interactions on the shape and total volume of 15 subcortical structures (p < .05, familywise error corrected). Associations with illness severity and duration were assessed in the BN group. RESULTS: Subcortical volumes did not differ across groups, but vertexwise analyses revealed inward shape deformations on the anterior surface of the pallidum in BN relative to control participants that were associated with binge-eating frequency and illness duration. Inward deformations on the ventrolateral thalamus and dorsal amygdala were more pronounced with advancing age in the BN group, and inward deformations on the caudate, putamen, and amygdala were associated with self-induced vomiting frequency. CONCLUSIONS: Our findings point to localized deformations on the surface of subcortical structures in areas that comprise both reward and cognitive control circuits. These deformations were more pronounced among older BN participants and among those with the most severe symptoms. Such precise localization of alterations in subcortical morphometry may ultimately aid in efforts to identify markers of risk and BN persistence.

AuthorBerner, Laura A.; Wang, Zhishun; Stefan, Mihaela; Lee, Seonjoo; Huo, Zhiyong; Cyr, Marilyn; Marsh, Rachel
JournalBiological psychiatry. Cognitive neuroscience and

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