The genetics of eating disorders

About this resource

Over the past decade, considerable advances have been made in understanding genetic influences on eating pathology. Eating disorders aggregate in families, and twin studies reveal that additive genetic factors account for approximately 40% to 60% of liability to anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Molecular genetics studies have been undertaken to identify alterations in deoxyribonucleic acid sequence and/or gene expression that may be involved in the pathogenesis of disordered eating behaviors, symptoms, and related disorders and to uncover potential genetic variants that may contribute to variability of treatment response. This article provides an in-depth review of the scientific literature on the genetics of AN, BN, and BED including extant studies, emerging hypotheses, future directions, and clinical implications.

AuthorTrace, Sara E.; Baker, Jessica H.; Pe~nas-Lledo, Eva & Bulik, Cynthia M.
JournalAnnual Review of Clinical Psychology
Volume9(1):589-620
Year2013

See also

Adipokines in anorexia nervosa: A systematic review and meta-analysis.

OBJECTIVE: The association between adipokine dysregulation and weight loss of patients with anorexia nervosa (AN) has been long investigated, in search of a causal relationship.

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The importance of eating behavior in eating disorders

A disturbance in eating behavior is the defining characteristic of the clinical eating disorders, Anorexia Nervosa, Bulimia Nervosa, and Binge Eating Disorder.

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Impaired theory of mind in unaffected first-degree relatives of patients with anorexia nervosa.

OBJECTIVE: Previous studies have shown theory of mind (ToM) is affected in patients with anorexia nervosa (AN).

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A qualitative exploration of influences on the process of recovery from personal written accounts of people with anorexia nervosa

Less than half of people with anorexia nervosa achieve full recovery.

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